5-CYANO-3-PYRIDINYL BORONIC ACID
5-cyano-3-pyridinyl boronic acid
CAS: 497147-93-0
Molecular Formula: C6H5BN2O2
5-CYANO-3-PYRIDINYL BORONIC ACID - Names and Identifiers
5-CYANO-3-PYRIDINYL BORONIC ACID - Physico-chemical Properties
| Molecular Formula | C6H5BN2O2 |
| Molar Mass | 147.93 |
| Density | 1.34 |
| Boling Point | 375.9±52.0 °C(Predicted) |
| Appearance | Crystalline Powder |
| Color | White to yellow |
| pKa | 5.52±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.561 |
| MDL | MFCD07374882 |
5-CYANO-3-PYRIDINYL BORONIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| HS Code | 29333999 |
5-CYANO-3-PYRIDINYL BORONIC ACID - Introduction
5-cyano-3-pyridinyl boronic acid is an organic compound with a chemical formula of C6H5BC4H4N and a molecular weight of 137.92.
Nature:
5-cyano-3-pyridinyl boronic acid is a white to light yellow crystalline powder, soluble in some organic solvents such as methanol and acetonitrile, but insoluble in water. It has good thermal stability and chemical stability.
Use:
5-cyano-3-pyridinyl boronic acid is an important organic synthesis intermediate, widely used in the field of chemical synthesis. It can participate as a boronate reagent in deoxygenation and cross-coupling reactions, such as the Suzuki coupling reaction. In addition, it can also be used to synthesize organic functional materials containing nitrogen, boron and pyridine groups, such as fluorescent dyes and photosensitive materials.
Preparation Method:
5-cyano-3-pyridinyl boronic acid is usually prepared by esterification of boric acid. The reaction of 3-pyridinol and cyanide produces 5-cyano-3-pyridinyl oxide, which then reacts with tributyl borate and is hydrolyzed to give 5-cyano-3-pyridinyl boronic acid.
Safety Information:
5-cyano-3-pyridinyl boronic acid is a relatively stable and low toxic compound under normal conditions. However, as with any chemical substance, it is still necessary to pay attention to safety precautions and follow relevant laboratory practice guidelines.
Nature:
5-cyano-3-pyridinyl boronic acid is a white to light yellow crystalline powder, soluble in some organic solvents such as methanol and acetonitrile, but insoluble in water. It has good thermal stability and chemical stability.
Use:
5-cyano-3-pyridinyl boronic acid is an important organic synthesis intermediate, widely used in the field of chemical synthesis. It can participate as a boronate reagent in deoxygenation and cross-coupling reactions, such as the Suzuki coupling reaction. In addition, it can also be used to synthesize organic functional materials containing nitrogen, boron and pyridine groups, such as fluorescent dyes and photosensitive materials.
Preparation Method:
5-cyano-3-pyridinyl boronic acid is usually prepared by esterification of boric acid. The reaction of 3-pyridinol and cyanide produces 5-cyano-3-pyridinyl oxide, which then reacts with tributyl borate and is hydrolyzed to give 5-cyano-3-pyridinyl boronic acid.
Safety Information:
5-cyano-3-pyridinyl boronic acid is a relatively stable and low toxic compound under normal conditions. However, as with any chemical substance, it is still necessary to pay attention to safety precautions and follow relevant laboratory practice guidelines.
Last Update：2024-04-10 22:29:15
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CAS: 497147-93-0
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View History
5-CYANO-3-PYRIDINYL BORONIC ACID
3-溴-1-苯基-5-(吡啶-2-基)吡啶-2(1H)-酮
3-MALEIMIDOPROPIONIC ACID HYDRAZONIUM, TRIFLUOROACETATE
受保护的美罗培南
Enalapril Impurity 1
(6-methylheptan-2-yl)[(2-phenyl-2H-1,2,3-triazol-4-yl)methyl]amine
4-氨基苯乙胺双盐酸盐
Phenol, 4-chloro-2-[[[2-(methylthio)phenyl]imino]methyl]-
13-methyldodecanoic acid methyl ester
3-hexadecyl-4-pentadecylideneoxetan-2-one
3-溴-1-苯基-5-(吡啶-2-基)吡啶-2(1H)-酮
3-MALEIMIDOPROPIONIC ACID HYDRAZONIUM, TRIFLUOROACETATE
受保护的美罗培南
Enalapril Impurity 1
(6-methylheptan-2-yl)[(2-phenyl-2H-1,2,3-triazol-4-yl)methyl]amine
4-氨基苯乙胺双盐酸盐
Phenol, 4-chloro-2-[[[2-(methylthio)phenyl]imino]methyl]-
13-methyldodecanoic acid methyl ester
3-hexadecyl-4-pentadecylideneoxetan-2-one